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Cerebral Adrenoleukodystrophy Market Insights, Epidemiology, and Market Forecast

Cerebral Adrenoleukodystrophy Market Insights, Epidemiology, and Market Forecast

January 22
14:19 2021
Cerebral Adrenoleukodystrophy Market Insights, Epidemiology, and Market Forecast

DelveInsight has launched a new report on Cerebral Adrenoleukodystrophy Market

Adrenoleukodystrophy (ALD) is an X-linked recessive genetic disorder caused by the abnormality in the ABCD1 gene present on the X chromosome that leads to the accumulation of very-long-chain fatty acids (VLCFAs) in the brain, nervous system, and adrenal gland. The accumulation of VLCFAs leads to the deterioration of the myelin sheath, and without the sheath, neurons cannot conduct action potentials, this leads to the development of seizures and hyperactivity. The disease mainly affects males (hemizygotes), but similar to other X-linked disorders, it is increasingly recognized that females (heterozygotes) may be clinically affected as well.

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The Cerebral Adrenoleukodystrophy market report provides an edge while developing business strategies, by understanding trends shaping and driving the global Cerebral Adrenoleukodystrophy market.

Cerebral Adrenoleukodystrophy Symptoms

The symptoms of CALD include learning disabilities, behavioral problems, bowel incontinence, adrenal insufficiency, loss of vision, deafness, seizures, loss of brain and muscle tissue. The tools for evaluating CALD include RI Severity Rating (Loes Score), NFS Score, and X-linked Adrenodystrophy-Disability Rating Scale (ALD-DRS).

Cerebral Adrenoleukodystrophy Key players

  • Bluebird Bio
  • Minoryx Therapeutics
  • Magenta Therapeutics
  • Orpheris Inc.

Cerebral Adrenoleukodystrophy Treatment

 General supportive care and symptomatic treatment for patient and family, provided by pediatrician or neurologist, with appropriate specialist consultation, nursing, schools, rehabilitation, and social agencies, are the cornerstones for the care and treatment of patients with CALD. Currently, there are no approved therapies for the treatment of CALD, and it is primarily managed by hormone replacement therapy, dietary therapy with Lorenzo’s oil, and Hematopoietic stem cell transplantation.

Cerebral Adrenoleukodystrophy Market

CALD occurs due to mutations of ABCD1 (Xq28,) encoding ALDP, a peroxisomal transmembrane protein involved in the transport of very long chain fatty acid CoA-esters (VLCFA) into the peroxisome; perturbing VLCFA homeostasis in glial cells contributes to myelin destabilization. This leads to severe neuroinflammation with impairment of the neuro-vascular unit followed by rapid functional decline.

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Table of content

1. Key Insights

2. Executive Summary of Cerebral Adrenoleukodystrophy (CALD)

3. Competitive Intelligence Analysis for Cerebral Adrenoleukodystrophy (CALD)

4. Cerebral Adrenoleukodystrophy (CALD) : Market Overview at a Glance

5. Cerebral Adrenoleukodystrophy (CALD) : Disease Background and Overview

6. Patient Journey

7. Cerebral Adrenoleukodystrophy (CALD) Epidemiology and Patient Population

8. Treatment Algorithm, Current Treatment, and Medical Practices

9. Unmet Needs

10. Key Endpoints of Cerebral Adrenoleukodystrophy (CALD) Treatment

11. Marketed Products

12. Emerging Therapies

13. Cerebral Adrenoleukodystrophy (CALD) : Seven Major Market Analysis

14. Attribute analysis

15. 7MM: Market Outlook

16. Access and Reimbursement Overview of Cerebral Adrenoleukodystrophy (CALD)

17. KOL Views

18. Market Drivers

19. Market Barriers

20. Appendix

21. DelveInsight Capabilities

22. Disclaimer

23. About DelveInsight

 

Reasons to buy

  • The report will help in developing business strategies by understanding trends shaping and driving the Cerebral Adrenoleukodystrophy (CALD) market
  • To understand the future market competition in the Cerebral Adrenoleukodystrophy (CALD) market and Insightful review of the key market drivers and barriers
  • Organize sales and marketing efforts by identifying the best opportunities for Cerebral Adrenoleukodystrophy (CALD) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors
  • Organize sales and marketing efforts by identifying the best opportunities for Cerebral Adrenoleukodystrophy (CALD) market
  • To understand the future market competition in the Cerebral Adrenoleukodystrophy (CALD) market

 

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